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Epigenetic, Autoimmune Diseases and Allergic Disease
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Hossein Esmaeilzadeh   , Seyed Alihossein Zahraie , Negar Mortazavi , Seyed Ali Dastgheib |
| Allergy Research center, Shiraz University of Medical Sciences, Shiraz, Iran |
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Abstract: (1895 Views) |
Background: Epigenetics is the study of how your behaviors and environment can cause changes that affect the way your genes work. Unlike genetic changes, epigenetic changes are reversible and do not change your DNA sequence, but they can change how your body reads a DNA sequence.Epigenetics is defined as inherited changes in gene expression, without actual changes in gene DNA sequence. Epigenetic modifications are biochemical changes in chromatin, DNA, or histones that are functionally related but do not affect the nucleotide sequence of the genome.Epigenetics and its role in autoimmune diseases and allergies were sought.
Methods: Pubmed and Google Scholar databases were searched using the key words: Epigenesis, autoimmune diseasesand allergic diseases for the past twenty years. Related articles were assessed and reviewed by the authors.
Results: Allergic and autoimmune diseases such as asthma, multiple sclerosis (MS) or rheumatoid arthritis (RA)can developed due to inappropriate immune responses to harmless foreign allergens (allergic disease) or to autoantigens (autoimmune disease).
Conclusion: Epigenetic mechanisms have recently been studied more extensively because they are environmentally influenced and can alter disease polymorphisms in a similar way.Epigenetic modifications affect (or are affected by) various environmental factors that both protect against allergies and transmit allergies.Changes in DNA methylation patterns may predict disease susceptibility prior to onset and be associated with a lack of persistent response to allergens.New technological approaches such as epigenetic editing and DNAzymes provide new methods for the treatment of allergic diseases |
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| Keywords: Autoimmune Diseases, Epigenomics, Hypersensitivity |
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Full-Text [PDF 710 kb]
(433 Downloads)
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Letter: Review Article |
Subject:
Special
Received: 2021/09/22 | Accepted: 2021/09/22 | Published: 2021/09/22
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