Background: This review was completed with the aim of tracing the results and outputs of the Academy’s researches activities over the past three decades, from its establishment through the year 2021. A persistent question has concerned the extent to which the results of research projects have been utilized in national documents and policymaking processes. Methods: This descriptive study was conducted through a comprehensive examination of available documents and archival materials. Library resources and research project contracts were reviewed to compile the full list of research project titles. Subsequently, internet searches and citation databases were explored using research keywords, along with the names and details of the principal investigators, to identify related outputs. Finally, supplementary information was obtained through direct telephone communication and email correspondence. Results: In this study, 527 research projects undertaken by the Academy of medical Sciences from its inception to the year 2021 were traced and analyzed according to their research methodologies. The Academy’s research orientation has evolved across different periods of activity, reflecting notable shifts in scientific and thematic focus. Guided by the formulation of strategic plans, research activities became increasingly structured, goal-oriented, and scientifically directed. The analysis of research outputs yielded 139 Persian and English articles, 68 books, 23 policy briefs, 25 advocacy documents, and 10 conferences. Conclusion: The findings indicate a progressive increase in both the number and quality of research projects implemented by the Academy over the past three decades. The diversity of research topics expanded in alignment with the first and second strategic plans. Furthermore, collaborative research initiatives with academic and scientific institutions demonstrated quantitative growth, consistent with the Academy’s strategic directions.