Background: One of the important challenges in various fields of medical sciences is to establish a logical relationship between concepts such as "heart", "soul", "mind", "soul" and the physical body of man. Knowing the characteristics of the soul and heart and guiding them correctly towards health is a requirement of conscious living and improves individual and social lifestyle.
The purpose of this study is to investigate the variety of interpretations related to the soul in the Holy Quran and their semantic relationship with each other and its impact on human health.
Methods: This study was conducted by library method and keyword search in international scientific databases. This study is analyzed in two sections: "Variety of self-interpretations" and "Impact of self-health".

The worst disease in humans is heart disease. Because it causes the misunderstanding of the truths and the loss of the most perfect happiness in the Hereafter, and it is a kind of death. Believer and guided hearts and infidel and unguided hearts with certain attributes are formed in the shadow of human behavior. Positive thinking, realism and self-care will improve the performance of the body's hormones and the health of the body.

Having a healthy breath, by affecting the health of hormones, causes a person's physical health and better relationships with fellow human beings and other components of life and the environment.