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Phylogenetic Study and Genetic Diversity of COVID-19 Virus Generator
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Masoomeh Jannesar   , Seyed Mahdi Seyedi |
| Member of Scientific Leadership Working Group, Academy of Medical Sciences, IR Iran |
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Abstract: (4155 Views) |
Background:The incidence of COVID-19 by the coronavirus SARS-CoV-2 with symptoms of acute respiratory syndrome in December 2019 in Wuhan, China, has spread rapidly and change to a global epidemics.
Methods:SARS-CoV-2 virus phylogenetic study performed to identify the genetic diversity of the prevalent viruses in Iran and compared with 6 selected countries.
Results:Phylogenetic study of SARS-CoV-2 virus showed the genetic variations generated in the virus genome are not currently sufficient to distinguish significant phylogenetic differences between the genome of viruses obtained from different geographical areas (19 countries from different continents) but can form variety of clusters. A study of the SARS-CoV-2 virus mutations showed that the prevalent viruses in Iran had six single-nucleotide (SNP) genetic variations in non-structural and structural genes and one insertion of six nucleotides in the RNA-dependent RNA polymerase gene region. Comparing the genetic variations of viruses in Iran with the six selected countries (India, the United States, Nepal, Italy, Spain and France) indicate the uniqueness of genetic variations of the prevalent viruses in Iran.
Conclusion: Studies show there is a direct connection between mutations in the SARS-CoV-2 virus genome and changes in pathogenesis. Therefore, regular assessment of the virus genetic diversity in each country can provide valuable data for the development of vaccines and drugs. |
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| Keywords: Acute Respiratory Syndrome, COVID-19, Genetic Variation |
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Full-Text [PDF 942 kb]
(3095 Downloads)
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Letter: Review Article |
Subject:
Special
Received: 2020/06/13 | Accepted: 2020/06/13 | Published: 2020/06/13
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